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Latest findings on the hepatocyte, scanned from PubMed, bioRxiv, and the journals. Updated every 10 minutes.
High-resolution spatial transcriptomics and proteomics map the full zonation gradient in healthy human liver; establishes reference atlas for normal at the molecular level before disease.
PAR3 polarity protein links hepatocyte proliferation to architectural restoration during regeneration; migratory ANXA2+ hepatocytes restore lobular zonation via wound-closure-mediated reorganization.
In vivo CRISPR interference screen in regenerating mouse liver identified NEURL1B as a regulator of mitotic spindle fidelity during hepatocyte division.
AI-enhanced image analysis of H&E and special stains reveals sex-specific differences in MASLD-driven HCC progression and regression.
Steatotic liver creates a pro-metastatic niche via altered zonation, oxygen gradients, lipid metabolism, and immune activity.
AI-assisted scoring of liver biopsies for steatosis, inflammation, ballooning, and fibrosis; reduces interobserver variability on special stains.
Comprehensive review of liver organoid systems: cholangiocyte and hepatocyte organoids, ductal-to-hepatocyte conversion, disease modeling for MASLD and cholestasis, and path to clinical translation.
Hippo silences Igf2 in postnatal hepatocytes to set liver size; chronic injury switches Hippo off and turns Igf2 back on, which regeneration requires. Aged mice fail to mount this response, and ectopic Igf2 restores it. Mouse; single study.
Ten liver pathologists scored MASLD slides by four methods; estimates varied with the method and ran systematically higher than AI-measured steatosis. Matters for every steatosis grade used in trials.
Modified pegRNAs with dense RNA motifs achieved ~70% prime editing efficiency in bulk mouse liver via a single lipid nanoparticle injection at clinically translatable dose; MS2 motif incorporation boosted base editing 11-fold. Mouse liver; single study.
FoxO1/3/4 directly regulate Ass1 (argininosuccinate synthetase 1), linking urea cycle nitrogen disposal to gluconeogenic output in hepatocytes; FoxO-deficient livers show impaired fasting glucose production and nitrogen handling. Mouse; single study.
Streamlined iPSC-to-hepatocyte protocol producing in vitro liver models with native complexity; designed for MASLD disease modelling and drug screening; human; preprint.